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Summary: The HbA1c test measures average blood glucose over 812 weeks and is a standard NHS diagnostic tool for type 2 diabetes, whilst the fasting insulin test assesses circulating insulin after an overnight fast and can indicate insulin resistance, though it is not routinely available on the NHS

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In essence, MOTS-c acts as a metabolic master switch that promotes energy homeostasis: it helps cells take up and use glucose, ramps up fat burning, and avoids metabolic dysfunction under stress conditions

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